Mechanisms and Management of Retinopathy of Prematurity

被引：12
作者：
Hartnett, M. Elizabeth [1 ,2 ,3 ]
Penn, John S. [4 ,5 ,6 ]
机构：
[1] Univ Utah, Moran Eye Ctr, Dept Ophthalmol, Salt Lake City, UT USA
[2] Univ Utah, Moran Eye Ctr, Dept Pediat, Salt Lake City, UT USA
[3] Univ Utah, Moran Eye Ctr, Dept Neurobiol & Anat, Salt Lake City, UT USA
[4] Vanderbilt Univ, Sch Med, Dept Ophthalmol & Visual Sci, Nashville, TN 37212 USA
[5] Vanderbilt Univ, Sch Med, Dept Cell & Dev Biol, Nashville, TN 37212 USA
[6] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37212 USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2012年 / 367卷 / 26期
关键词：
ENDOTHELIAL GROWTH-FACTOR; OXYGEN-INDUCED RETINOPATHY; PROLYL HYDROXYLASE INHIBITION; RETINAL NEOVASCULARIZATION; CELL-DIVISION; MOUSE MODEL; RAT MODEL; VITAMIN-E; INTRAVITREOUS NEOVASCULARIZATION; NEUTRALIZING ANTIBODY;
D O I：
10.1056/NEJMra1208129
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Models of oxygen-induced retinopathy have elucidated how oxygen stresses may lead to the development of retinopathy of prematurity through activated signaling pathways. Screening is currently carried out according to the guidelines in Table 1. Current treatment for severe retinopathy of prematurity focuses on laser therapy and visual rehabilitation, and potential new treatment strategies include targets within oxidative pathways, erythropoietin, and anti-VEGF agents. Copyright © 2012 Massachusetts Medical Society.
引用
收藏
页码：2515 / 2526
页数：12
相关论文
共 80 条
  • [1] SUPPRESSION OF RETINAL NEOVASCULARIZATION IN-VIVO BY INHIBITION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR (VEGF) USING SOLUBLE VEGF-RECEPTOR CHIMERIC PROTEINS
    AIELLO, LP
    PIERCE, EA
    FOLEY, ED
    TAKAGI, H
    CHEN, H
    RIDDLE, L
    FERRARA, N
    KING, GL
    SMITH, LEH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (23) : 10457 - 10461
  • [2] EFFECT OF OXYGEN ON DEVELOPING RETINAL VESSELS WITH PARTICULAR REFERENCE TO THE PROBLEM OF RETROLENTAL FIBROPLASIA
    ASHTON, N
    WARD, B
    SERPELL, G
    [J]. BRITISH JOURNAL OF OPHTHALMOLOGY, 1954, 38 (07) : 397 - 432
  • [3] Brooks SE, 2001, INVEST OPHTH VIS SCI, V42, P222
  • [4] Association between higher cumulative doses of recombinant erythropoietin and risk for retinopathy of prematurity
    Brown, Mark S.
    Baron, Anna E.
    France, Eric K.
    Hamman, Richard F.
    [J]. JOURNAL OF AAPOS, 2006, 10 (02): : 143 - 149
  • [5] Higher Cumulative Doses of Erythropoietin and Developmental Outcomes in Preterm Infants
    Brown, Mark S.
    Eichorst, Delphine
    LaLa-Black, Brenda
    Gonzalez, Robin
    [J]. PEDIATRICS, 2009, 124 (04) : E681 - E687
  • [6] Reduction in endothelial tip cell filopodia corresponds to reduced intravitreous but not intraretinal vascularization in a model of ROP
    Budd, Steven
    Byfield, Grace
    Martiniuk, David
    Geisen, Pete
    Hartnett, Mary Elizabeth
    [J]. EXPERIMENTAL EYE RESEARCH, 2009, 89 (05) : 718 - 727
  • [7] Buonocore G, 2001, BIOL NEONATE, V79, P180
  • [8] The Role of Supplemental Oxygen and JAK/STAT Signaling in Intravitreous Neovascularization in a ROP Rat Model
    Byfield, Grace
    Budd, Steve
    Hartnett, M. Elizabeth
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2009, 50 (07) : 3360 - 3365
  • [9] Target Ranges of Oxygen Saturation in Extremely Preterm Infants.
    Carlo, Waldemar A.
    Finer, Neil N.
    Walsh, Michele C.
    Rich, Wade
    Gantz, Marie G.
    Laptook, Abbot R.
    Yoder, Bradley A.
    Faix, Roger G.
    Das, Abhik
    Poole, W. Kenneth
    Schibler, Kurt
    Newman, Nancy S.
    Ambalavanan, Namasivayam
    Frantz, Ivan D., III
    Piazza, Anthony J.
    Sanchez, Pablo J.
    Morris, Brenda H.
    Laroia, Nirupama
    Phelps, Dale L.
    Poindexter, Brenda B.
    Cotten, C. Michael
    Van Meurs, Krisa P.
    Duara, Shahnaz
    Narendran, Vivek
    Sood, Beena G.
    O'Shea, T. Michael
    Bell, Edward F.
    Ehrenkranz, Richard A.
    Watterberg, Kristi L.
    Higgins, Rosemary D.
    Jobe, A. H.
    Caplan, M. S.
    Oh, W.
    Hensman, A. M.
    Gingras, D.
    Barnett, S.
    Lillie, S.
    Francis, K.
    Andrews, D.
    Angela, K.
    Fanaroff, A. A.
    Siner, B. S.
    Zadell, A.
    DiFiore, J.
    Donovan, E. F.
    Bridges, K.
    Alexander, B.
    Grisby, C.
    Mersmann, M. W.
    Mincey, H. L.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (21) : 1959 - 1969
  • [10] CHANLING TL, 1995, INVEST OPHTH VIS SCI, V36, P1201
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