Hippocampal volume in subjects at clinical high-risk for psychosis: A systematic review and meta-analysis

被引：34

作者：

Walter, Anna ^{[1
]}

Suenderhauf, Claudia ^{[2
]}

Harrisberger, Fabienne ^{[1
]}

Lenz, Claudia ^{[1
]}

Smieskova, Renata ^{[1
]}

Chung, Yoonho ^{[3
]}

Cannon, Tyrone D. ^{[3
]}

Bearden, Carrie E. ^{[4
,5
,6
]}

Rapp, Charlotte ^{[7
]}

Bendfeldt, Kerstin ^{[8
]}

Borgwardt, Stefan ^{[1
]}

Vogel, Tobias ^{[1
]}

机构：

[1] Psychiat Univ Clin UPK, Basel, Switzerland

[2] Univ Basel Hosp, Clin Pharmacol & Toxicol, Basel, Switzerland

[3] Yale Univ, Dept Psychol, New Haven, CT USA

[4] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA USA

[5] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA

[6] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Brain Res Inst, Los Angeles, CA USA

[7] Psychiat Clin Solothurn, Ctr Psychosis Treatment, Solothurn, Switzerland

[8] Univ Basel, Med Image Anal Ctr, Basel, Switzerland

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2016年 / 71卷

关键词：

Hippocampus; Clinical high-risk; Biomarker; Magnetic resonance imaging; At-risk mental state; Ultra high-risk; Psychosis; Early detection; ULTRA-HIGH-RISK; CHRONIC-SCHIZOPHRENIA; 1ST-EPISODE SCHIZOPHRENIA; AMYGDALA VOLUMES; INDIVIDUALS; REDUCTION; DOPAMINE; STRESS; ONSET; STATE;

D O I：

10.1016/j.neubiorev.2016.10.007

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Several magnetic resonance imaging studies have reported reductions in hippocampal volume in patients with psychosis. It is unclear whether structural abnormalities predate illness onset. We conducted a detailed, systematic literature search for studies reporting hippocampal volume in subjects with clinical high-risk, compared to healthy controls. The overall sample size comprised 1429 subjects. Meta-analysis revealed no difference for left, but a small, albeit significant, difference for right hippocampal volume, such that clinical high-risk patients had slightly smaller hippocampal volume than healthy controls (g = 0.24, p = 0.0418). Meta-regression indicated a moderating effect of manual tracing approach, due to one outlying site. The small difference on the right side did not remain significant (g = 0.14, 95%CI = [-0.03-0.32], p=0.11) after removal of this outlier. This meta-analysis suggests that there is no reduction in hippocampal volume before transition to psychosis and hippocampal volume cannot be used as a biomarker in clinical high-risk individuals. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：680 / 690

页数：11

共 85 条

[1] Hippocampal Volume Reduction in First-Episode and Chronic Schizophrenia: A Review and Meta-Analysis [J].