Bioactive Diterpenes from Callicarpa longissima

被引：33

作者：

Liu, Yuan-Wei ^{[1
]}

Cheng, Yuan-Bin ^{[1
]}

Liaw, Chia-Ching ^{[1
]}

Chen, Chung-Hsiung ^{[1
]}

Guh, Jih-Hwa ^{[1
]}

Hwang, Tsong-Long ^{[2
]}

Tsai, Ji-Shu ^{[3
]}

Wang, Won-Bo ^{[3
]}

Shen, Ya-Ching ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 100, Taiwan

[2] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[3] Natl Taiwan Univ, Coll Med, Grad Inst Microbiol, Taipei 100, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 04期

关键词：

CONSTITUENTS; TERPENOIDS; AMERICANA; LEAVES;

D O I：

10.1021/np200932k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Investigation of the leaves and twigs of Callicarpa longissima resulted in the isolation of four new compounds (14), callilongisins A-D, and five known compounds, ursolic acid, 3-oxoanticopalic acid, (E)-6 beta-hydroxylabda-8(17),13-dien-15-oic acid, 5-hydroxy-3,6,7,4'-tetramethoxyflavone, and artemetin. Compounds 1-3 are 3,4-seco-abietane-type diterpenoids, and compound 4 is an analogue of a labdenoic-type diterpene. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Cytotoxicity against a human prostate cancer cell line (PC3) and anti-inflammatory activities of the isolated compounds were evaluated.

引用

页码：689 / 693

页数：5

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