Eight Months of Serological Follow-Up of Anti-SARS-CoV-2 Antibodies in France: A Study among an Adult Population

被引:0
作者
Decarreaux, Dorine [1 ,2 ,3 ]
Sevila, Julie [1 ]
Masse, Shirley [1 ]
Capai, Lisandru [1 ]
Fourie, Toscane [3 ]
Villarroel, Paola Mariela Saba [3 ]
Amroun, Abdennour [3 ]
Nurtop, Elif [3 ]
Vareille, Matthieu [1 ]
Blanchon, Thierry [2 ]
de Lamballerie, Xavier [3 ]
Charrel, Remi [3 ]
Falchi, Alessandra [1 ]
机构
[1] Univ Corse Pascal Paoli, Lab Virol, UR7310 Bioscope, F-20250 Corte, France
[2] Sorbonne Univ, Inst Pierre Louis Epidemiol & Sante Publ, INSERM, IPLESP, F-75012 Paris, France
[3] Aix Marseille Univ, Unite Virus Emergents, IHU Mediterranee Infect, INSERM U1207,IRD 190, F-13005 Marseille, France
关键词
COVID-19; seroconversion; long-lasting immunity; antibodies; vaccination; SARS-COV-2; INFECTION; COVID-19;
D O I
10.3390/ijerph192215257
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: Uncertainties remain regarding the nature and durability of the humoral immune response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Aim: This study investigated immunoglobulin G response and neutralizing activity to evaluate the mean antibody concentrations and response duration induced by each vaccination regimen in a French adult population. Methods: A study including blood sampling and questionnaires was carried out from November 2020 to July 2021 with three separate follow-up phases. Spike proteins and neutralizing antibodies were quantified using ELISA and a virus-neutralization test. Results: Overall, 295 participants were included. Seroprevalences were 11.5% (n = 34), 10.5% (n = 31), and 68.1% (n = 201) in phases 1, 2, and 3, respectively. Importantly, 5.8% (n = 17) of participants lost their natural antibodies. Antibody response of participants with only a prior infection was 88.2 BAU/mL, significantly lower than those vaccinated, which was 1909.3 BAU/mL (p = 0.04). Moreover, the antibody response of vaccinated participants with a prior infection was higher (3593.8 BAU/mL) than those vaccinated without prior infection (3402.9 BAU/mL) (p = 0.78). Vaccinated participants with or without prior infection had a higher seroneutralization rate (91.0%) than those unvaccinated with prior infection (65.0%). Conclusion: These results demonstrated that single infection does not confer effective protection against SARS-CoV-2.
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页数:19
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