A case of Fabry disease with central nervous system (CNS) demyelinating lesions: a double trouble?

被引：11

作者：

Invernizzi, P. ^{[1
]}

Bonometti, M. A. ^{[1
]}

Turri, E. ^{[1
]}

Benedetti, M. D. ^{[1
]}

Salviati, A. ^{[1
]}

机构：

[1] Univ Verona, Policlin GB Rossi, Neurol Clin, Dept Neurol Sci & Vis,Sect Clin Neurol, I-37100 Verona, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2008年 / 14卷 / 07期

关键词：

evoked potentials; Fabry disease; magnetic resonance imaging; multiple sclerosis; oligoclonal bands; white matter lesions;

D O I：

10.1177/1352458508092355

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present the case of a 36-year-old woman affected with Fabry disease (FD), with neuroradiologic and laboratory tests suggestive of a coexistent inflammatory demyelinating disease. Since the age of 23, she presented recurrent neurologic deficits, such as right limb paresthesias, diplopia, and right leg weakness. Magnetic resonance imaging revealed multiple demyelinating lesions in periventricular areas, corpus callosum, and spinal cord. Cerebrospinal fluid analysis showed the presence of oligoclonal bands, while visual-evoked potentials were delayed with preserved morphology. FD is usually considered as a differential diagnosis of multiple sclerosis, but we think that the best explanation of all pathological features in this case is the coexistence of the two diseases.

引用

页码：1003 / 1006

页数：4

共 15 条

[1]

Arias Martinez N, 2003, An Med Interna, V20, P28

[2]

Callegaro D, 2006, Int MS J, V13, P27

[3] Natural history of Fabry disease in females in the Fabry outcome survey [J].