In Vitro Antiprotozoal Activity of Some Xanthones Isolated from the Roots of Andrographis paniculata

被引：26

作者：

Dua, Virendra K. ^{[1
]}

Verma, Gaurav ^{[1
]}

Dash, A. P. ^{[2
]}

机构：

[1] BHEL Corp, Natl Inst Malaria Res, Field Unit, Hardwar 249403, India

[2] Natl Inst Malaria Res, Delhi 110054, India

来源：

PHYTOTHERAPY RESEARCH | 2009年 / 23卷 / 01期

关键词：

Andrographis paniculata; in vitro activity; xanthones; T; b; brucer; cruzi; L; infantum; BARK;

D O I：

10.1002/ptr.2556

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four xanthones isolated from the roots of Andrographis paniculata were tested in vitro for antiprotozoal activity against Trypanosoma brucei brucei, Trypanosonia cruzi and Leishmania infantum. Compound TDR13011 (1,2-dihydroxy-6,8-dimethoxy-xanthone) showed good activity against T. b. brucei and L. infantum with a 50% inhibitory concentration (IC50) of 4.6 mu g/ml and 8 mu g/ml respectively. Xanthones from the roots of Andrographis paniculata exhibited promising anti-protozoal activity and these compounds could be chemically modified to obtain a more potent product. Copyright (c) 2008 John Wiley & Sons, Ltd.

引用

页码：126 / 128

页数：3

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