Gene-Environment Interaction

被引：172

作者：

Manuck, Stephen B. ^{[1
]}

McCaffery, Jeanne M. ^{[2
,3
]}

机构：

[1] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

[2] Brown Univ, Miriam Hosp, Dept Psychiat & Human Behav, Providence, RI 02903 USA

[3] Brown Univ, Warren Alpert Sch Med, Providence, RI 02903 USA

来源：

ANNUAL REVIEW OF PSYCHOLOGY, VOL 65 | 2014年 / 65卷

关键词：

behavioral genetics; heritability; diathesis-stress; differential susceptibility; vantage sensitivity; gene-environment correlation; SEROTONIN TRANSPORTER GENE; GENOME-WIDE ASSOCIATION; STRESSFUL LIFE EVENTS; DOPAMINE-RECEPTOR D4; BODY-MASS INDEX; DIFFERENTIAL SUSCEPTIBILITY; EXTERNALIZING BEHAVIOR; INDIVIDUAL-DIFFERENCES; PHYSICAL-ACTIVITY; CANDIDATE GENE;

D O I：

10.1146/annurev-psych-010213-115100

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

With the advent of increasingly accessible technologies for typing genetic variation, studies of gene-environment (GxE) interactions have proliferated in psychological research. Among the aims of such studies are testing developmental hypotheses and models of the etiology of behavioral disorders, defining boundaries of genetic and environmental influences, and identifying individuals most susceptible to risk exposures or most amenable to preventive and therapeutic interventions. This research also coincides with the emergence of unanticipated difficulties in detecting genetic variants of direct association with behavioral traits and disorders, which may be obscured if genetic effects are expressed only in predisposing environments. In this essay we consider these and other rationales for positing GxE interactions, review conceptual models meant to inform GxE interpretations from a psychological perspective, discuss points of common critique to which GxE research is vulnerable, and address the role of the environment in GxE interactions.

引用

页码：41 / 70

页数：30

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