Expression of UTX Indicates Poor Prognosis in Patients With Luminal Breast Cancer and is Associated With MMP-11 Expression

被引：4

作者：

Kim, Gi Jeong ^{[1
,2
]}

Kim, Dong-Hoon ^{[3
]}

Min, Kyueng-Whan ^{[4
]}

Chae, Seoung Wan ^{[3
]}

Kim, Se Hoon ^{[5
]}

Son, Byoung Kwan ^{[6
]}

Moon, Kyoung Min ^{[7
]}

Kim, Young Hwan ^{[8
]}

机构：

[1] Gachon Univ, Gil Med Ctr, Dept Pathol, Coll Med, Incheon, South Korea

[2] Yonsei Univ, Grad Sch, Dept Med, Seoul, South Korea

[3] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Pathol, Sch Med, 29 Saemunan Ro, Seoul 03181, South Korea

[4] Hanyang Univ, Coll Med, Guri Hosp, Dept Pathol, Guri, Gyeonggi Do, South Korea

[5] Yonsei Univ, Severance Hosp, Dept Pathol, Coll Med, Seoul, South Korea

[6] Eulji Univ, Eulji Hosp, Dept Internal Med, Sch Med, Seoul, South Korea

[7] Univ Ulsan, Gangneung Asan Hosp, Dept Internal Med, Coll Med, Kangnung, South Korea

[8] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Nucl Med, Sch Med, Seoul, South Korea

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2020年 / 28卷 / 07期

关键词：

breast cancer; UTX; MMP-11; prognosis; molecular classification; MATRIX METALLOPROTEINASES; HISTONE VARIANTS; DEMETHYLASE UTX; PROLIFERATION;

D O I：

10.1097/PAI.0000000000000795

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is involved in the epigenetic regulation. A previous mouse xenograft study revealed that UTX knockdown is associated with downregulated expression of matrix metalloproteinase-11 (MMP-11). The authors investigated 224 cases of breast cancer from Kangbuk Samsung Medical Center between 2000 and 2005. Nuclear UTX and cytoplasmic MMP-11 expressions were assessed using immunohistochemistry of tumor tissue microarray specimens. The relationships between the expression of UTX, MMP-11, and patients' outcomes were analyzed. UTX expression was significantly associated with high histologic grade, lymphatic invasion, vascular invasion, and tumoral expression of MMP-11. Survival analysis revealed that patients with UTX expression had a poorer overall survival rate (P=0.010) as well as diminished disease-free survival rate (P=0.001). The prognostic power of UTX expression was significant in patients with luminal-type breast cancer (P=0.027, overall survival;P=0.008, disease-free survival). Validation of UTX can provide further prognostic information beyond traditional indicators and represents a potential therapeutic target for breast cancer.

引用

页码：544 / 550

页数：7

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