Very slow decline of hepatitis B virus surface antigen and core related antigen in chronic hepatitis B patients successfully treated with nucleos(t)ide analogues

被引：7
作者：
Alidjinou, Enagnon K. [1 ]
Michel, Charlotte [1 ]
Canva, Valerie [2 ]
Ajana, Faiza [3 ]
Hober, Didier [1 ]
Bocket, Laurence [1 ]
机构：
[1] Univ Lille, CHU Lille, Fac Med, Lab Virol EA3610, Lille, France
[2] CHU Lille, Serv Malad Appareil Digestif, Lille, France
[3] CH Dron, Serv Univ Malad Infect, Tourcoing, France
来源：
JOURNAL OF MEDICAL VIROLOGY | 2018年 / 90卷 / 05期
关键词：
chronic hepatitis; HBcrAg; HBsAg; HBV; nucleos(t)ide analogues; CLOSED CIRCULAR DNA; VIRAL-DNA; REDUCTION; MARKER;
D O I：
10.1002/jmv.25028
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We investigated the decline of hepatitis B virus surface antigen (HBsAg) and core related antigen (HBcrAg) in chronic hepatitis B patients sussessfully treated with nucleos(t)ide analogues. In patients with plasma viral suppression, the baseline median levels of HBsAg and HBcrAg were 3.1 and 3.0log U/mL, respectively. The levels in naive patients were 4.2 and 3.6log U/mL for HBsAg and HBcrAg, respectively. No significant decline was observed in patients with viral suppression within a year period. A low reduction was observed during the first months after treatment initiation, especially regarding HBcrAg. The dynamics of these antigens after viral suppression should be further investigated.
引用
收藏
页码：989 / 993
页数：5
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