Cortical kindling in a focal freeze lesion rat model

被引：2

作者：

Takase, Kei-ichiro ^{[1
]}

Shigeto, Hiroshi ^{[1
]}

Suzuki, Satoshi O. ^{[2
]}

Kikuchi, Hitoshi ^{[1
]}

Ohyagi, Yasumasa ^{[1
]}

Kira, Jun-ichi ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Neurol, Neurol Inst,Higashi Ku, Fukuoka 8128582, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Neuropathol, Neurol Inst,Higashi Ku, Fukuoka 8128582, Japan

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2009年 / 16卷 / 01期

关键词：

Epilepsy; Focal cortical dysplasia; Freeze lesion model; Epileptogenicity; Kindling; TEMPORAL-LOBE EPILEPSY; DUAL PATHOLOGY; INTRINSIC EPILEPTOGENICITY; HYPERTHERMIC SEIZURES; NEURONAL MIGRATION; DYSPLASTIC CORTEX; FEBRILE SEIZURES; ANIMAL-MODEL; IMMATURE RAT; BRAIN;

D O I：

10.1016/j.jocn.2008.04.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Focal cortical dysplasia (FCD) is of increasing interest as a cause of focal epilepsy. We aimed to determine whether the existence of FCD influences the epileptogenicity induced by electrical kindling stimulation of the cortices. We created an FCD rat model by focal contact of a frozen metal probe on the scalp immediately after birth. To produce afterdischarges (ADs), electrical stimulation was applied to the frontal cortices once daily for 20 consecutive days from postnatal day 38 (P38). Thresholds and durations of ADs were measured. Brains were exposed and examined histologically at P58. We observed mild FCD, which consisted of disorganized cortices with extra sulci: however, there was no statistical difference in the thresholds or durations of ADs between FCD rats and control animals. These results suggest that FCD might not influence vulnerability to epileptogenicity, at least in some patients with fluid FCD. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：94 / 98

页数：5