Enantioselective synthesis of α,β-diamino ester derivatives: memory of chirality in imino-aldol reactions

被引：19

作者：

Ghorai, Manas K. ^{[1
]}

Ghosh, Koena ^{[1
]}

Yadav, A. K. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 04期

关键词：

Memory of chirality; Enolate; Imino-aldol; alpha; beta-Diamino esters; Aziridine; ACID-DERIVATIVES; AMINO-ACIDS; ASYMMETRIC CYCLIZATION; STEREOSELECTIVE-SYNTHESIS; ALKYLATION REACTIONS; NONRACEMIC ENOLATE; MANNICH REACTIONS; ALPHA-ALKYLATION; AXIAL CHIRALITY; QUATERNARY;

D O I：

10.1016/j.tetlet.2008.11.050

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple strategy for the synthesis of chiral alpha,beta-diamino ester derivatives in good yields and ee (up to 92%) utilizing the 'memory of chirality' concept is reported. This methodology has been extended for the enantioselective synthesis of substituted aziridines with excellent ee (92%). (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：476 / 479

页数：4

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