MitoAnalyzer, a computer program and interactive web site to determine the effects of single nucleotide polymorphisms and mutations in human mitochondrial DNA

被引：15

作者：

Lee, MS ^{[1
]}

Levin, BC ^{[1
]}

机构：

[1] NIST, Biotechnol Div, Gaithersburg, MD 20899 USA

来源：

MITOCHONDRION | 2002年 / 1卷 / 04期

关键词：

computer program; human; mitochondrial DNA; mutations; single nucleotide polymorphisms; web site;

D O I：

10.1016/S1567-7249(01)00031-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MitoAnalyzer provides information about the effects of single nucleotide polymorphisms (SNPs) and mutations in human mitochondrial DNA (mtDNA). This program determines if a single base pair (bp) change is in the non-coding or coding region, in the first, second or third bp of the codon, in a rRNA, tRNA or a protein, causes an amino acid (aa) change, the nature of that change, the position of the aa change in the protein, and the new aa sequence of the changed protein. Mutations associated with published mitochondrial diseases are noted. This program, thus, facilitates rapid analysis and evaluation of SNPs and mutations in human mtDNA. Published by Elsevier Science B.V. and Mitochondria Research Society.

引用

页码：321 / 326

页数：6

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