Structural Bioinformatics study of PNP from Listeria monocytogenes

被引：11
作者：
Timmers, L. F. S. M. [1 ]
Caceres, R. A. [1 ]
Basso, L. A. [1 ,2 ]
Santos, D. S. [2 ]
De Azevedo, W. F., Jr. [1 ]
机构：
[1] Pontificia Univ Catolica Rio Grande do Sul, Fac Biociencias, Porto Alegre, RS, Brazil
[2] Pontificia Univ Catolica Rio Grande do Sul, Ctr Pesquisas Biol Mol & Func, Inst Pesquisas Biomed, Porto Alegre, RS, Brazil
来源：
PROTEIN AND PEPTIDE LETTERS | 2008年 / 15卷 / 08期
关键词：
Purine Nucleoside Phosphorylase; molecular modeling; bioinformatics; drug design; Listeria monocytogenes;
D O I：
10.2174/092986608785203728
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This work describes for the first time a model of Purine Nucleoside Phosphorylase from Listeria monocytogenes (LmPNP). We modeled the complexes of LmPNP with ligands in order to determine the structural basis for specificity. Comparative analysis of the model of LmPNP allowed identification of structural features responsible for ligand affinities.
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收藏
页码：843 / 849
页数：7
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