Impact of inactivated poliovirus vaccine on mucosal immunity: implications for the polio eradication endgame

被引:48
作者
Parker, Edward P. K. [1 ]
Molodecky, Natalie A. [1 ]
Pons-Salort, Margarita [1 ]
O'Reilly, Kathleen M. [1 ]
Grassly, Nicholas C. [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, London, England
基金
英国惠康基金; 比尔及梅琳达.盖茨基金会; 英国医学研究理事会;
关键词
environmental surveillance; eradication; inactivated poliovirus vaccine; mucosal immunity; oral poliovirus vaccine; poliovirus; PREEXISTING HOMOTYPIC ANTIBODIES; QUANTITATIVE RELATIONSHIP; ROUTINE IMMUNIZATION; INTESTINAL IMMUNITY; HOUSEHOLD CONTACTS; IMMUNOGLOBULIN-A; LIVE VIRUS; POLIOMYELITIS; EXCRETION; IMMUNOGENICITY;
D O I
10.1586/14760584.2015.1052800
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The polio eradication endgame aims to bring transmission of all polioviruses to a halt. To achieve this aim, it is essential to block viral replication in individuals via induction of a robust mucosal immune response. Although it has long been recognized that inactivated poliovirus vaccine (IPV) is incapable of inducing a strong mucosal response on its own, it has recently become clear that IPV may boost immunity in the intestinal mucosa among individuals previously immunized with oral poliovirus vaccine. Indeed, mucosal protection appears to be stronger following a booster dose of IPV than oral poliovirus vaccine, especially in older children. Here, we review the available evidence regarding the impact of IPV on mucosal immunity, and consider the implications of this evidence for the polio eradication endgame. We conclude that the implementation of IPV in both routine and supplementary immunization activities has the potential to play a key role in halting poliovirus transmission, and thereby hasten the eradication of polio.
引用
收藏
页码:1113 / 1123
页数:11
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