Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II)

被引：8
|
作者：
Lopez Zeballos, Noelia C. [1 ]
Marino, Julieta [2 ]
Garcia Vior, Maria C. [3 ]
Chiarante, Nicolas [2 ]
Roguin, Leonor P. [2 ]
Awruch, Josefina [3 ]
Dicelio, Lelia E. [1 ]
机构：
[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Inorgan Analit & Quim Fis, INQUIMAE, RA-1428 Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Fac Farm & Bioquim, Inst Quim & Fis Quim Biol UBA CONICET, RA-1113 Buenos Aires, DF, Argentina
[3] Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Organ, RA-1113 Buenos Aires, DF, Argentina
来源：
DYES AND PIGMENTS | 2013年 / 96卷 / 03期
关键词：
Photodynamic therapy; Phthalocyanine; Liposome; Singlet oxygen; Photocytotoxicity; KB cells; PHOTODYNAMIC THERAPY; ZINC PHTHALOCYANINE; BASIC PRINCIPLES; PHOTOSENSITIZERS; AGGREGATION; OXYGEN; STATE;
D O I：
10.1016/j.dyepig.2012.11.005
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Six novel liposomal formulations of 2,9(10),16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl] phthalocyaninatozinc(II) (Pc9) were investigated to establish how the environments affect their photophysical and photobiological properties. The incorporation efficiency and solubility during a time period were evaluated. All Pc9-liposomal formulations were efficient singlet oxygen quantum yield generators. The photobiological potentials were evaluated on human nasopharynx KB carcinoma cells. None of the formulations studied showed cytotoxic effects in the absence of light, whereas all of them showed good performance after irradiation. The 50% inhibition of cell proliferation (IC50) was in the range of 0.21-0.47 mu M for Pc9-loaded liposome formulations. A lysosomal localization was found for S-PEG as well as for S. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：626 / 635
页数：10
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