Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans

被引：78

作者：

Ackermann, Katrin ^{[1
]}

Plomp, Rosina ^{[1
]}

Lao, Oscar ^{[1
]}

Middleton, Benita ^{[2
]}

Revell, Victoria L. ^{[2
]}

Skene, Debra J. ^{[2
]}

Kayser, Manfred ^{[1
]}

机构：

[1] Erasmus MC Univ Med Ctr Rotterdam, Dept Forens Mol Biol, Rotterdam, Netherlands

[2] Univ Surrey, Fac Hlth & Med Sci, Ctr Chronobiol, Guildford GU2 5XH, Surrey, England

来源：

CHRONOBIOLOGY INTERNATIONAL | 2013年 / 30卷 / 07期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Circadian clock; circadian rhythms; clock genes; oxidative stress; sleep deprivation; BLOOD MONONUCLEAR-CELLS; PERIPHERAL CIRCADIAN CLOCKS; PLASMA MELATONIN; OXIDATIVE STRESS; PHASE; LIGHT; WAKE; LEUKOCYTES; CORTISOL; RECOVERY;

D O I：

10.3109/07420528.2013.784773

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study investigated the impact of sleep deprivation on the human circadian system. Plasma melatonin and cortisol levels and leukocyte expression levels of 12 genes were examined over 48 h (sleep vs. no-sleep nights) in 12 young males (mean +/- SD: 23 +/- 5 yrs). During one night of total sleep deprivation, BMAL1 expression was suppressed, the heat shock gene HSPA1B expression was induced, and the amplitude of the melatonin rhythm increased, whereas other high-amplitude clock gene rhythms (e. g., PER1-3, REV-ERB alpha) remained unaffected. These data suggest that the core clock mechanism in peripheral oscillators is compromised during acute sleep deprivation.

引用

页码：901 / 909

页数：9

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