Arginine-rich Peptides: Methods of Translocation Through Biological Membranes

被引：0

作者：

Futaki, Shiroh ^{[1
]}

Hirose, Hisaaki ^{[1
]}

Nakase, Ikuhiko ^{[1
]}

机构：

[1] Kyoto Univ, Inst Chem Res, Uji, Kyoto 6110011, Japan

来源：

CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 16期

关键词：

Cell-penetrating peptide; arginine; macropinocytosis; membrane-associated proteoglycan; direct translocation; membrane potential; counterion; membrane curvature; CELL-PENETRATING PEPTIDES; HUMAN IMMUNODEFICIENCY VIRUS; HIV-TAT PEPTIDE; INTRACELLULAR DELIVERY; INTERNALIZATION MECHANISMS; PERMEABLE PEPTIDES; BILAYER-MEMBRANES; PLASMA-MEMBRANE; POTENTIAL ROLE; IN-VIVO;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intracellular delivery using cell-penetrating peptides (CPPs) has received considerable attention as a promising method for introducing exogenous molecules into cells. The mechanisms that enable efficient internalization of CPPs together with cargo molecules are also of interest. In this review, we describe our current views of membrane translocation of CPPs, especially those rich in arginine, as these peptides represent one of the most frequently employed classes of CPPs.

引用

页码：2863 / 2868

页数：6

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