Strategies for targeting the DNA damage response for cancer therapeutics

被引：4
|
作者：
Zhang, Dan [1 ,2 ]
Wang, Hai-Bo [2 ]
Brinkman, Kathryn L. [2 ]
Han, Su-Xia [1 ]
Xu, Bo [2 ]
机构：
[1] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Radiat Oncol, Xian 710061, Peoples R China
[2] Methodist Hosp, Res Inst, Dept Radiat Oncol, Houston, TX 77030 USA
来源：
CHINESE JOURNAL OF CANCER | 2012年 / 31卷 / 08期
关键词：
DNA damage response; DNA repair; synthetic lethality; PARP inhibitors; DEPENDENT PROTEIN-KINASE; SYNTHETIC LETHALITY; MUTANT-CELLS; INHIBITION; INIPARIB; ATM;
D O I：
10.5732/cjc.012.10087
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.
引用
收藏
页码：359 / 363
页数：5
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