Urinary Citrate Is Associated with Kidney Outcomes in Early Polycystic Kidney Disease

被引：9
作者：
Rocha, Daniel Ribeiro [1 ]
Xue, Laixi [2 ]
Gomes Sousa, Hiago Murilo [1 ]
Carvalho Matos, Ana Christina [1 ]
Hoorn, Ewout J. [2 ]
Salih, Mahdi [2 ]
Heilberg, Ita Pfeferman [1 ]
机构：
[1] Univ Fed Sao Paulo UNIFESP, Div Nephrol, Sao Paulo, Brazil
[2] Erasmus MC, Dept Internal Med, Div Nephrol & Transplantat, Rotterdam, Netherlands
来源：
KIDNEY360 | 2022年 / 3卷 / 12期
关键词：
cystic kidney disease; ADPKD; CKD; eGFR; polycystic kidney disease; urinary citrate; CRITERIA; THERAPY;
D O I：
10.34067/KID.0004772022
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Key Points Low urinary citrate and crystal deposition accelerated cystogenesis in an experimental model of polycystic kidney disease (PKD). Hypocitraturia, frequently observed in patients with autosomal dominant PKD (ADPKD) could contribute to disease progression. Present findings suggest lower urinary citrate in early PKD was associated with faster eGFR decline and worse kidney survival.
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收藏
页码：2110 / 2115
页数：6
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