Industrially viable synthesis of 3[3-(trifluoromethyl)phenyl]propionaldehyde. A key intermediate of cinacalcet

被引：0
|
作者：
Chavakula, Ramadas [1 ]
Mutyala, Naraynna Rao [1 ]
Chennupati, Srinivasa Rao [1 ]
机构：
[1] Tyche Ind Ltd, Hyderabad 500093, Andhra Pradesh, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2013年 / 90卷 / 08期
关键词：
Calcimimetics; cinacalcet; Corey-Kim oxidation; NCS; dimethyl sulfide;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An improved synthesis of 3[3-(trifluoromethyl)phenyl]propionaldehyde (2), a key intermediate of cinacalcet hydrochloride ((R)-alpha-methyl-N[3-[3-triflouoromethyl)phenyl]propyl]-1-naphthalene methane amine hydrochloride) has been described. The key step include the Corey-Kim oxidation under normal conditions.
引用
收藏
页码：1259 / 1261
页数：3
相关论文
共 50 条
  • [31] Quantitative Investigation of Polymorphism in 3-(Trifluoromethyl)-N-[2-(trifluoromethyl)phenyl]benzamide
    Panini, Piyush
    Bhandary, Subhrajyoti
    Chopra, Deepak
    CRYSTAL GROWTH & DESIGN, 2016, 16 (05) : 2561 - 2572
  • [32] N,N-dimethyl-N′-[3-(trifluoromethyl)phenyl]urea
    Yu, Da-sheng
    Li, Fang-shi
    Yao, Wei
    Liu, Yin-hong
    Lu, Chui
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1220 - U1482
  • [33] Practical synthesis of methyl(E)-2-(3-(3-(2-(7-chloro-2- quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate,a key intermediate of Montelukast
    Liang He~a
    ChineseChemicalLetters, 2012, 23 (05) : 518 - 520
  • [34] Practical synthesis of methyl (E)-2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate, a key intermediate of Montelukast
    He, Liang
    Guo, Yang Hui
    Wang, Ya Ping
    Wang, Xiang Jing
    Zhang, Ji
    Xiang, Wen Sheng
    CHINESE CHEMICAL LETTERS, 2012, 23 (05) : 518 - 520
  • [35] Synthesis and Single Crystal X-ray Studies of 3-(3,5-Bis(trifluoromethyl)phenyl) Quinoline and 3-(4-Fluoro-3-methylphenyl) Quinoline
    Malik Aman Ullah
    Muhammad Adeel
    Muhammad Nawaz Tahir
    Muhammad Raza Shah
    Irfan Ullah
    Chinese Journal of Structural Chemistry, 2014, (01) : 90 - 96
  • [36] Synthesis and Single Crystal X-ray Studies of 3-(3,5-Bis(trifluoromethyl)phenyl) Quinoline and 3-(4-Fluoro-3-methylphenyl) Quinoline
    Ullah, Malik Aman
    Adeel, Muhammad
    Tahir, Muhammad Nawaz
    Shah, Muhammad Raza
    Ullah, Irfan
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2014, 33 (01) : 90 - 96
  • [37] Synthesis of 4-[4'-bis(2''-chloroethyl)aminophenyl]-3-(trifluoromethyl)butanoic acid [3-(trifluoromethyl)chlorambucil]
    Coe, PL
    Markou, M
    Tatlow, JC
    JOURNAL OF FLUORINE CHEMISTRY, 1997, 84 (02) : 113 - 118
  • [38] Synthesis and Single Crystal X-ray Studies of 3-(3,5-Bis(trifluoromethyl)phenyl) Quinoline and 3-(4-Fluoro-3-methylphenyl) Quinoline
    Malik Aman Ullah
    Muhammad Adeel
    Muhammad Nawaz Tahir
    Muhammad Raza Shah
    Irfan Ullah
    结构化学, 2014, 33 (01) : 90 - 96
  • [39] 1-(2,6-dichlorobenzoyl)-3-[(3-trifluoromethyl)-phenyl]thiourea
    Rauf, M. Khawar
    Badshah, Amin
    Bolte, Michael
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O4299 - O4301
  • [40] Facile synthesis, DNA binding, Urease inhibition, anti-oxidant, molecular docking and DFT studies of 3-(3-Bromo-phenyl)-1-(2-trifluoromethyl-phenyl)-propenone and 3-(3-Bromo-5 chloro-phenyl)-1-(2-trifluoromethyl-phenyl)-propenone
    Rasool, Faiz
    Khalid, Muhammad
    Yar, Muhammad
    Ayub, Khurshid
    Tariq, Muhammad
    Hussain, Ajaz
    Lateef, Mehreen
    Kashif, Muhammad
    Iqbal, Sana
    JOURNAL OF MOLECULAR LIQUIDS, 2021, 336
12345