Industrially viable synthesis of 3[3-(trifluoromethyl)phenyl]propionaldehyde. A key intermediate of cinacalcet

被引：0
|
作者：
Chavakula, Ramadas [1 ]
Mutyala, Naraynna Rao [1 ]
Chennupati, Srinivasa Rao [1 ]
机构：
[1] Tyche Ind Ltd, Hyderabad 500093, Andhra Pradesh, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2013年 / 90卷 / 08期
关键词：
Calcimimetics; cinacalcet; Corey-Kim oxidation; NCS; dimethyl sulfide;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An improved synthesis of 3[3-(trifluoromethyl)phenyl]propionaldehyde (2), a key intermediate of cinacalcet hydrochloride ((R)-alpha-methyl-N[3-[3-triflouoromethyl)phenyl]propyl]-1-naphthalene methane amine hydrochloride) has been described. The key step include the Corey-Kim oxidation under normal conditions.
引用
收藏
页码：1259 / 1261
页数：3
相关论文
共 50 条
  • [21] SYNTHESIS OF NEW TANDOSPIRONE ANALOGUES CARRYING 1-(3-(TRIFLUOROMETHYL)PHENYL)PIPERAZINE
    Gunkara, Omer Tahir
    Sucu, Bilgesu Onur
    Guleli, Muge
    Ocal, Nuket
    SYNTHETIC COMMUNICATIONS, 2014, 44 (11) : 1619 - 1628
  • [22] Methyl 3-(4-{6-methyl-4-[3-(trifluoromethyl)phenyl]pyridazin-3-yloxy}phenyl)propanoate
    Xiao, Yu-Hong
    Zhu, You-Quan
    Zou, Xiao-Mao
    Hu, Fang-Zhong
    Yang, Hua-Zheng
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1044 - U1881
  • [23] Design, Synthesis and Gibberellin-Like Activity of Novel 1-Substituted 3-[3-(Trifluoromethyl)phenyl]thiourea Derivatives
    Yang, Zhikun
    Xu, Jiahui
    Bai, Yumeng
    Wang, Zhao
    Duan, Liusheng
    Tan, Weiming
    JOURNAL OF PLANT GROWTH REGULATION, 2022, 41 (04) : 1845 - 1853
  • [24] Design, Synthesis and Gibberellin-Like Activity of Novel 1-Substituted 3-[3-(Trifluoromethyl)phenyl]thiourea Derivatives
    Zhikun Yang
    Jiahui Xu
    Yumeng Bai
    Zhao Wang
    Liusheng Duan
    Weiming Tan
    Journal of Plant Growth Regulation, 2022, 41 : 1845 - 1853
  • [25] N-phenylethyl-N′-[3-(trifluoromethyl)phenyl]-thiourea
    Chopra, D
    Choudhury, AR
    Nagarajan, K
    Row, TNG
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2004, 60 : O1970 - O1971
  • [26] Facile synthesis of 3-(trifluoromethyl)adamantane derivatives
    Zhyhadlo, Yevheniia Y.
    Gaidai, Alexander V.
    Levandovskiy, Igor A.
    Bezdudny, Andriy V.
    Rassukana, Yuliya V.
    JOURNAL OF FLUORINE CHEMISTRY, 2017, 201 : 11 - 14
  • [27] Enzymatic resolution of 3-(3-indolyl)butyric acid: a key intermediate for indolmycin synthesis
    Kato, K
    Tanaka, S
    Gong, YF
    Katayama, M
    Kimoto, H
    WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 1999, 15 (05): : 631 - 633
  • [28] Enzymatic resolution of 3-(3-indolyl)butyric acid: a key intermediate for indolmycin synthesis
    Katsuya Kato
    Satoko Tanaka
    Yue-Fa Gong
    Masato Katayama
    Hiroshi Kimoto
    World Journal of Microbiology and Biotechnology, 1999, 15 : 631 - 633
  • [29] Synthesis and properties of 1-(3-(fluoromethyl and trifluoromethyl)phenyl)-5-oxopyrrolidine-3-carboxylic acid derivatives
    Vytautas Mickevičius
    Rita Vaickelionienė
    Ilona Jonuškienė
    Gema Mikulskienė
    Kristina Kantminienė
    Monatshefte für Chemie - Chemical Monthly, 2009, 140 : 1513 - 1522
  • [30] Synthesis and properties of 1-(3-(fluoromethyl and trifluoromethyl)phenyl)-5-oxopyrrolidine-3-carboxylic acid derivatives
    Mickevicius, Vytautas
    Vaickelioniene, Rita
    Jonuskiene, Ilona
    Mikulskiene, Gema
    Kantminiene, Kristina
    MONATSHEFTE FUR CHEMIE, 2009, 140 (12): : 1513 - 1522
12345