Industrially viable synthesis of 3[3-(trifluoromethyl)phenyl]propionaldehyde. A key intermediate of cinacalcet

被引：0
|
作者：
Chavakula, Ramadas [1 ]
Mutyala, Naraynna Rao [1 ]
Chennupati, Srinivasa Rao [1 ]
机构：
[1] Tyche Ind Ltd, Hyderabad 500093, Andhra Pradesh, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2013年 / 90卷 / 08期
关键词：
Calcimimetics; cinacalcet; Corey-Kim oxidation; NCS; dimethyl sulfide;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An improved synthesis of 3[3-(trifluoromethyl)phenyl]propionaldehyde (2), a key intermediate of cinacalcet hydrochloride ((R)-alpha-methyl-N[3-[3-triflouoromethyl)phenyl]propyl]-1-naphthalene methane amine hydrochloride) has been described. The key step include the Corey-Kim oxidation under normal conditions.
引用
收藏
页码：1259 / 1261
页数：3
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