Protective antioxidant effect of garlic against cypermethrin induced lung toxicity in adult male mice: Biochemical and Histopathological studies

In the present study, the protective effect of garlic against cypermethrin -induced lung toxicity was studied. Adult male mice (N=20) with average weight 18- 20 g were used in the study. Animals were divided into four groups of 5 each: group I control received corn oil; group II received cypermethrin (2.8 mg/kg BW) in corn oil. Group III received garlic (500 mg/kg BW); group IV received both cypermethrin and garlic. All treatments were given by oral gavage for 14 days. The results showed that cypermethrin increased thiobarbituric acid-reactive substances (TBARS) and decreased activities of the antioxidant enzymes (GST: glutathione S - transferase; -SH group; SOD: superoxide dismutase). Lung injury was confirmed by histopathological changes. Animals treated with garlic and cypermethrin together showed that lung TBARS returned to the control level which indicating a protective effect of garlic. Also, garlic was able to increase the reduced activities of the antioxidant enzymes induced by cypermethrin. In addition, garlic protected the lung from histological changes induced by cypermethrin. In conclusion, garlic was found to provide protective effect against and cypermethrin induced damage in mice alveoli and bronchioles with the attenuation of the oxidative stress and the preservation in antioxidant enzymes. It could be advised as an as Therefore this effective dietary supplements in developing countries where pesticide pollution is high. [Turki M. Al-Shaikh. Protective antioxidant effect of garlic against cypermethrin induced lung toxicity in adult male mice: Biochemical and Histopathological studies. Life Sci J 2012;9(4):4017-4025]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 599