Synthesis of Benzopyran Linked Pyrrolo[2,1-c][1,4]benzodiazepines as DNA-Binding and Potential Anticancer Agents

被引：2

作者：

Kamal, Ahmed ^{[1
]}

Reddy, Rajender Methuku Kashi ^{[1
]}

Reddy, Vangala Santhosh ^{[1
]}

Kumar, Gajjela Bharath ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Ctr Chem Biol, Hyderabad 500607, Andhra Pradesh, India

来源：

MEDICINAL CHEMISTRY | 2013年 / 9卷 / 02期

关键词：

Cytotoxicity; DNA-Binding affinity; 2,2-Dimethyl benzopyran; Pyrrolo[2,1-c][1,4]benzodiazepines and Piperazine; PYRROLOBENZODIAZEPINE DIMERS; COMBINATORIAL LIBRARIES; ANTITUMOR ANTIBIOTICS; PRIVILEGED STRUCTURES; SEQUENCE SPECIFICITY; BIOLOGICAL-ACTIVITY; AFFINITY; DESIGN; CYTOTOXICITY; ABILITY;

D O I：

10.2174/1573406411309020003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of twelve benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized. They exhibit significant DNA-binding activity and excellent cytotoxic activity against various human cancer cell lines.

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收藏

页码：177 / 192

页数：16

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