Association between Remnant-Like Particle Cholesterol and Gamma-Glutamyltransferase in Dyslipidemic Patients

Objective: To investigate the correlation between gammaglutamyltransferase (GGT) and remnant-like particle cholesterol (RLP-C) in dyslipidemic patients. Subjects and Methods: General cardiometabolic variables, plus serum GGT and RLP-C levels, were measured in 118 dyslipidemic patients (59 males, mean age 58 +/- 13 years). Correlation analyses of GGT with other variables, including RLP-C, were performed. Results: The median levels (interquartile ranges) of RLP-C and GGT were 0.21 mmol/l (0.14-0.35) and 26 IU/l (17-39), respectively. A stepwise multiple regression analysis revealed an independent, significant and positive correlation between GGT and RLP-C (beta = 0.351, p < 0.001), followed by male gender and BMI. Conclusion: There was a significant positive association between GGT and RLP-C, thereby indicating that the association between GGT and cardiovascular disease may be partly due to the interaction with RLP-C in dyslipidemic patients. Further research is therefore warranted to confirm the observed relationship. Copyright (C) 2012 S. Karger AG, Basel