Aluminum speciation studies in biological fluids Part 5. A quantitative investigation of Al(III) complex equilibria with desferrioxamine, 2,3-dihydroxybenzoic acid, Tiron, CP20 (L1), and CP94 under physiological conditions, and computer-aided assessment of the aluminum-mobilizing capacities of these ligands in vivo

While the involvement of environmental aluminum toxicity in the advent of senile dementias is still debated, acute aluminum toxicity of iatrogenic origin is well documented. So far, the only treatment available against it has been desferrioxamine (DFO), which induces major side effects. New drugs are thus highly desirable, and possible DFO substitutes have already been considered through various techniques. An important test for such new drugs is to assess their Al-mobilizing capacity in vivo. This can be done by computer-aided speciation provided formation constants for the corresponding AI(III) complexes are known beforehand. The present work reports an investigation of Al(III) complex equilibria with five sequestering ligands including DFO, and predicts the respective capacities of these to mobilize aluminum in vivo under normal and inflammatory conditions. (C) 1999 Elsevier Science Inc. All rights reserved.