Endothelial Dysfunction in Diabetes

被引：54

作者：

Takeda, Yusuke ^{[1
]}

Matoba, Keiichiro ^{[1
]}

Sekiguchi, Kensuke ^{[1
]}

Nagai, Yosuke ^{[1
]}

Yokota, Tamotsu ^{[1
]}

Utsunomiya, Kazunori ^{[2
]}

Nishimura, Rimei ^{[1
]}

机构：

[1] Jikei Univ, Dept Internal Med, Div Diabet Metab & Endocrinol, Sch Med, Tokyo 1058461, Japan

[2] Jikei Univ, Ctr Prevent Med, Sch Med, Tokyo 1058461, Japan

来源：

BIOMEDICINES | 2020年 / 8卷 / 07期

基金：

日本学术振兴会;

关键词：

endothelial dysfunction; insulin resistance; macrophage polarity; GLUCAGON-LIKE PEPTIDE-1; NF-KAPPA-B; DIPEPTIDYL PEPTIDASE-4 INHIBITORS; CORONARY-ARTERY-DISEASE; NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; RHO-KINASE; MACROPHAGE POLARIZATION; OXIDATIVE STRESS; PPAR-GAMMA;

D O I：

10.3390/biomedicines8070182

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetes is a worldwide health issue closely associated with cardiovascular events. Given the pandemic of obesity, the identification of the basic underpinnings of vascular disease is strongly needed. Emerging evidence has suggested that endothelial dysfunction is a critical step in the progression of atherosclerosis. However, how diabetes affects the endothelium is poorly understood. Experimental and clinical studies have illuminated the tight link between insulin resistance and endothelial dysfunction. In addition, macrophage polarization from M2 towards M1 contributes to the process of endothelial damage. The possibility that novel classes of anti-hyperglycemic agents exert beneficial effects on the endothelial function and macrophage polarization has been raised. In this review, we discuss the current status of knowledge regarding the pathological significance of insulin signaling in endothelium. Finally, we summarize recent therapeutic strategies against endothelial dysfunction with an emphasis on macrophage polarity.

引用

页数：15

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