Antiteratogenic effect of resveratrol in mice exposed in utero to 2,3,7,8-tetrachlorodibenzo-p-dioxin

被引：18

作者：

Jang, Ja Young ^{[1
,2
]}

Park, Dongsun ^{[1
,2
]}

Shin, Sunhee ^{[1
,2
]}

Jeon, Jeong Hee ^{[1
,2
]}

Choi, Byong-il ^{[1
,2
]}

Joo, Seong Soo ^{[1
,2
]}

Hwang, Seock-Yeon ^{[3
]}

Nahm, Sang-Seop ^{[4
]}

Kim, Yun-Bae ^{[1
,2
]}

机构：

[1] Chungbuk Natl Univ, Coll Vet Med, Cheongju 361763, Chungbuk, South Korea

[2] Chungbuk Natl Univ, Vet Med Res Inst, Cheongju 361763, Chungbuk, South Korea

[3] Juseong Coll, Dept Clin Lab Sci, Cheongwon 363794, Chungbuk, South Korea

[4] Konkuk Univ, Coll Vet Med, Seoul 143701, South Korea

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2008年 / 591卷 / 1-3期

关键词：

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin); malformation; cleft palate; hydronephrosis; aryl hydrocarbon receptor antagonist; resveratrol;

D O I：

10.1016/j.ejphar.2008.05.033

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of resveratrol, an aryl hydrocarbon receptor antagonist, on the teratogenicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated. Pregnant C57BL/6J mice were orally administered resveratrol (50 mg/kg) for 6 consecutive days, from gestational day (Go) 8 to GD13, followed by an oral challenge with TCDD (14 mu g/kg) on GD12. TCDD caused severe fetal malformations including cleft palate (40.7%), renal pelvic dilatation (100%, mean score 3.060), and ureteric dilatation (100%, mean score 3.210) and tortuosity (95.1%). Resveratrol significantly reduced both the incidence of TCDD-induced cleft palate to 18.4% and the degrees of renal pelvic and ureteric dilatations caused by TCDD. The results suggest that pretreatment with resveratrol might bring a beneficial outcome for reducing the incidence and severity of fetal malformations caused by TCDD exposure in utero. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：280 / 283

页数：4

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