Advances in characterisation and biological activities of chitosan and chitosan oligosaccharides

被引：340
作者：
Zou, Pan [1 ,2 ]
Yang, Xin [1 ,2 ]
Wang, Jing [1 ,2 ,3 ]
Li, Yongfei [2 ,3 ]
Yu, Hailong [2 ,3 ]
Zhang, Yanxin [1 ,2 ]
Liu, Guangyang [1 ,2 ]
机构：
[1] Harbin Inst Technol, Sch Chem Engn & Technol, Dept Food Sci & Engn, Harbin 150090, Heilongjiang Pr, Peoples R China
[2] Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Key Lab Agroprod Qual & Safety, Beijing 100081, Peoples R China
[3] Minist Agr, Key Lab Agrifood Safety & Qual, Beijing 100081, Peoples R China
来源：
FOOD CHEMISTRY | 2016年 / 190卷
基金：
中国国家自然科学基金;
关键词：
Chitosan; Chitosan oligosaccharides; Biological activities; Physicochemical; Anti-tumour; Mechanism; MOLECULAR-WEIGHT CHITOSAN; HEXA-N-ACETYLCHITOHEXAOSE; WATER-SOLUBLE CHITOSAN; ANTIMICROBIAL ACTIVITY; ANTIBACTERIAL ACTIVITY; BIOMEDICAL APPLICATIONS; ENZYMATIC-HYDROLYSIS; ANTICANCER ACTIVITY; SURFACE-CHARGE; CHITOOLIGOSACCHARIDES;
D O I：
10.1016/j.foodchem.2015.06.076
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Chitosan and chitosan oligosaccharides (COS) have been reported to possess various biomedical properties, including antimicrobial activities, immuno-enhancing effects, and anti-tumour activities. COS have attracted considerable interest due to their physicochemical properties, and potential applications in the food and pharmaceutical industries, especially in cancer therapies. This paper describes the preparation of COS and their physicochemical properties, and modification, which aids understanding of their biological activities. Based on the latest reports, several biological and anti-tumour activities of COS will be discussed. The proposed anti-tumour mechanisms of COS are summarised, to provide comprehensive insights into research on the molecular level. Finally, the potential applications and future development of the biopolymer will be discussed. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1174 / 1181
页数：8
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