Gene expression regulations by long noncoding RNAs and their roles in cancer

被引：19

作者：

Du, Xin-hui ^{[1
]}

Wei, Hua ^{[2
]}

Qu, Guo-xin ^{[1
]}

Tian, Zhi-chao ^{[1
]}

Yao, Wei-tao ^{[1
]}

Cai, Qi-qing ^{[1
]}

机构：

[1] Zhengzhou Univ, Affiliated Canc Hosp, Henan Canc Hosp, Dept Orthoped, Zhengzhou, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Anesthesiol, Zhengzhou, Peoples R China

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2020年 / 216卷 / 06期

关键词：

LncRNAs; LncRNA functions; LncRNA binding partners; multiple types of Cancer; METASTASIS;

D O I：

10.1016/j.prp.2020.152983

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Cancers are deadly diseases. The general mystery of carcinogenesis, primary and acquired drug resistance and distant organ metastasis are still puzzles to be solved. Long noncoding RNAs (lncRNAs) are receiving more and more attention in recent years since their roles in transcriptional regulation have been unveiled. Detailed functional annotations of lncRNAs have showed that their regulatory roles are largely determined by their binding partners. LncRNAs directly bind to DNA, RNA and proteins and regulate gene expression at transcriptional, post-transcriptional and post-translational levels. Here we review the current understanding of molecular functions of lncRNAs, will emphasize on their binding partners and summarize their biological roles in cancer.

引用

页数：6

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