Nitroalkylation - A redox sensitive signaling pathway

被引：34

作者：

Geisler, Anne C. ^{[2
]}

Rudolph, Tanja K. ^{[1
]}

机构：

[1] Univ Hamburg, Univ Heart Ctr, Dept Gen & Intervent Cardiol, Cardiovasc Res Ctr, D-20246 Hamburg, Germany

[2] Univ Hamburg, Univ Heart Ctr, Dept Electrophys, Cardiovasc Res Ctr, D-20246 Hamburg, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2012年 / 1820卷 / 06期

关键词：

Nitrated fatty acids; Nitroalkylation; Electrophile; Nitric oxide; NF-KAPPA-B; FATTY-ACID TRANSDUCTION; PROTEIN S-NITROSYLATION; NITRO-LINOLEIC ACID; MATRIX METALLOPROTEINASES; GENE-EXPRESSION; HEME OXYGENASE-1; MOLECULAR-MECHANISMS; NITROLINOLEIC ACID; ANTIINFLAMMATORY DRUGS;

D O I：

10.1016/j.bbagen.2011.06.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Redox-sensitive posttranslational modification emerged as important signaling mechanisms. Besides other posttranslational modifications nitroalkylation by nitrated fatty acids mediate favorable anti-inflammatory effects. This review gives an overview of the generation and the reactivity of nitrated fatty acids. Additionally, it provides insights into the so far described pathways regulated by nitrated fatty acids. This article is part of a Special Issue entitled Regulation of Cellular Processes by S-nitrosylation. (C) 2011 Elsevier B.V. All rights reserved.

引用

收藏

页码：777 / 784

页数：8

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