The role of FOXOs and autophagy in cancer and metastasis-Implications in therapeutic development

被引：40
作者：
Farhan, Mohd [1 ]
Silva, Marta [1 ]
Li, Shuai [1 ]
Yan, Fengxia [2 ]
Fang, Jiankang [1 ]
Peng, Tangming [1 ]
Hu, Jim [3 ]
Tsao, Ming-Sound [3 ]
Little, Peter [4 ]
Zheng, Wenhua [1 ]
机构：
[1] Univ Macau, Inst Translat Med, Ctr Reprod Dev & Aging, Fac Hlth Sci, Taipa, Macau, Peoples R China
[2] Jinan Univ, Dept Med, Guangzhou, Peoples R China
[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[4] Univ Queensland, Sch Pharm Pharm Australia Ctr Excellence, Woolloongabba, Qld, Australia
来源：
MEDICINAL RESEARCH REVIEWS | 2020年 / 40卷 / 06期
基金：
中国国家自然科学基金;
关键词：
autophagy; cancer; FOXO proteins; metastasis; OXIDATIVE-STRESS RESPONSES; TRANSCRIPTION FACTORS; SIGNALING PATHWAY; DOWN-REGULATION; CELL-SURVIVAL; STEM-CELLS; PHASE-II; SUPPRESSES AUTOPHAGY; TARGETING AUTOPHAGY; TUMOR-METASTASIS;
D O I：
10.1002/med.21695
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Autophagy is a highly conserved intracellular degradation process that plays a crucial role in cell survival and stress reactions as well as in cancer development and metastasis. Autophagy process involves several steps including sequestration, fusion of autophagosomes with lysosomes and degradation. Forkhead box O (FOXO) transcription factors regulate the expression of genes involved in cellular metabolic activity and signaling pathways of cancer growth and metastasis. Recent evidence suggests that FOXO proteins are also involved in autophagy regulation. The relationship among FOXOs, autophagy, and cancer has been drawing attention of many who work in the field. This study summarizes the role of FOXO proteins and autophagy in cancer growth and metastasis and analyzes their potential roles in cancer disease management.
引用
收藏
页码：2089 / 2113
页数：25
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