Selective and Efficient Mitochondrial Staining with Designed 2,1,3-Benzothiadiazole Derivatives as Live Cell Fluorescence Imaging Probes

被引：0

作者：

Neto, Brenno A. D. ^{[1
]}

Correa, Jose R. ^{[1
]}

Carvalho, Pedro H. P. R. ^{[1
]}

Santos, Diego C. B. D. ^{[1
]}

Guido, Bruna C. ^{[1
]}

Gatto, Claudia C. ^{[1
]}

de Oliveira, Heibbe C. B. ^{[1
]}

Fasciotti, Maira ^{[2
]}

Eberlin, Marcos N. ^{[2
]}

da Silva, Eufranio N., Jr. ^{[3
]}

机构：

[1] Univ Brasilia, Inst Chem, Lab Med & Technol Chem, BR-70904970 Brasilia, DF, Brazil

[2] Univ Campinas UNICAMP, ThoMSon Mass Spectrometry Lab, BR-13083970 Campinas, SP, Brazil

[3] Univ Fed Minas Gerais, Dept Chem, Inst Exact Sci, BR-31270901 Belo Horizonte, MG, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2012年 / 23卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

benzothiadiazole; synthesis; mitochondria; cellular staining; ELECTROCHEMICAL PROPERTIES; PHOTOPHYSICAL PROPERTIES; SENSITIVE FLUOROPHORES; CONJUGATED POLYMER; OPTICAL-PROPERTIES; DNA; DYES; PHOTOLUMINESCENCE; PRINCIPLES; BEARING;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel designed 2,1,3-benzothiadiazole fluorescent probes were synthesized, characterized and applied as live cell fluorescence imaging probe staining only mitochondria in mammalian cancer cell lines (MCF-7). The efficiency of these new probes was found to be much superior to that of the commercially available MitoTracker (R) Red. Cellular and in vitro experiments allowed better understanding of the relationship between the planned molecular architecture of the new dyes and the observed cellular selectivity.

引用

页码：770 / 781

页数：12

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