Selective and Efficient Mitochondrial Staining with Designed 2,1,3-Benzothiadiazole Derivatives as Live Cell Fluorescence Imaging Probes

被引：0

作者：

Neto, Brenno A. D. ^{[1
]}

Correa, Jose R. ^{[1
]}

Carvalho, Pedro H. P. R. ^{[1
]}

Santos, Diego C. B. D. ^{[1
]}

Guido, Bruna C. ^{[1
]}

Gatto, Claudia C. ^{[1
]}

de Oliveira, Heibbe C. B. ^{[1
]}

Fasciotti, Maira ^{[2
]}

Eberlin, Marcos N. ^{[2
]}

da Silva, Eufranio N., Jr. ^{[3
]}

机构：

[1] Univ Brasilia, Inst Chem, Lab Med & Technol Chem, BR-70904970 Brasilia, DF, Brazil

[2] Univ Campinas UNICAMP, ThoMSon Mass Spectrometry Lab, BR-13083970 Campinas, SP, Brazil

[3] Univ Fed Minas Gerais, Dept Chem, Inst Exact Sci, BR-31270901 Belo Horizonte, MG, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2012年 / 23卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

benzothiadiazole; synthesis; mitochondria; cellular staining; ELECTROCHEMICAL PROPERTIES; PHOTOPHYSICAL PROPERTIES; SENSITIVE FLUOROPHORES; CONJUGATED POLYMER; OPTICAL-PROPERTIES; DNA; DYES; PHOTOLUMINESCENCE; PRINCIPLES; BEARING;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel designed 2,1,3-benzothiadiazole fluorescent probes were synthesized, characterized and applied as live cell fluorescence imaging probe staining only mitochondria in mammalian cancer cell lines (MCF-7). The efficiency of these new probes was found to be much superior to that of the commercially available MitoTracker (R) Red. Cellular and in vitro experiments allowed better understanding of the relationship between the planned molecular architecture of the new dyes and the observed cellular selectivity.

引用

页码：770 / 781

页数：12

共 40 条

[1]

Cao H., 2009, [No title captured], Patent No. [CN101550234, 101550234]

[2] Design of cationic conjugated polyelectrolytes for DNA concentration determination [J].

Chi, Chunyan ;

Mikhailovsky, Alexander ;

Bazan, Guillermo C. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (36) :11134-11145

[3] Cytometric Assessment of Mitochondria Using Fluorescent Probes [J].

Cottet-Rousselle, Cecile ;

Ronot, Xavier ;

Leverve, Xavier ;

Mayol, Jean-Francois .

CYTOMETRY PART A, 2011, 79A (06) :405-425

[4] New Low Bandgap Conjugated Polymer Derived from 2, 7-Carbazole and 5, 6-Bis(octyloxy)-4, 7-di(thiophen-2-yl) Benzothiadiazole: Synthesis and Photovoltaic Properties [J].

Ding, Ping ;

Chu, Cheng-Che ;

Zou, Yingping ;

Xiao, Dequan ;

Pan, Chunyue ;

Hsu, Chain-Shu .

JOURNAL OF APPLIED POLYMER SCIENCE, 2012, 123 (01) :99-107

[5] Donor-Acceptor-Donor-based π-Conjugated Oligomers for Nonlinear Optics and Near-IR Emission [J].

Ellinger, Stefan ;

Graham, Kenneth R. ;

Shi, Pengjie ;

Farley, Richard T. ;

Steckler, Timothy T. ;

Brookins, Robert N. ;

Taranekar, Prasad ;

Mei, Jianguo ;

Padilha, Lazaro A. ;

Ensley, Trenton R. ;

Hu, Honghua ;

Webster, Scott ;

Hagan, David J. ;

Van Stryland, Eric W. ;

Schanze, Kirk S. ;

Reynolds, John R. .

CHEMISTRY OF MATERIALS, 2011, 23 (17) :3805-3817

[6] Synthesis and Photophysical Characterizations of Thermal -Stable Naphthalene Benzimidazoles [J].

Erten-Ela, Sule ;

Ozcelik, Serdar ;

Eren, Esin .

JOURNAL OF FLUORESCENCE, 2011, 21 (04) :1565-1573

[7] Synthesis and chemical properties of new photoluminescent poly(p-phenyleneethynylene) containing an electron-accepting benzothiadiazole unit and an electron-donating dialkoxybenzene unit -: Effect of twisting of the main chain on photoluminescence [J].

Fang, Q ;

Tanimoto, A ;

Yamamoto, T .

SYNTHETIC METALS, 2005, 150 (01) :73-78

[8] Application of d6 transition metal complexes in fluorescence cell imaging [J].

Fernandez-Moreira, Vanesa ;

Thorp-Greenwood, Flora L. ;

Coogan, Michael P. .

CHEMICAL COMMUNICATIONS, 2010, 46 (02) :186-202

[9] Theoretical study of the lowest electronic transitions of sulfur-bearing mesoionic compounds in gas-phase and in dimethyl sulfoxide [J].

Fonseca, T. L. ;

de Oliveira, H. C. B. ;

Castro, M. A. .

CHEMICAL PHYSICS LETTERS, 2008, 457 (1-3) :119-123

[10] N-Aryl-9-amino-substituted acridizinium derivatives as fluorescent "light-up" probes for DNA and protein detection [J].

Granzhan, A ;

Ihmels, H .

ORGANIC LETTERS, 2005, 7 (23) :5119-5122

← 1 2 3 4 →