Role of Cannabinoid Receptors in Bone Disorders: Alternatives for Treatment

被引:10
作者
Idris, Aymen I.
机构
[1] Bone Research Group, Rheumatic Diseases Unit, University of Edinburgh
关键词
D O I
10.1358/dnp.2008.21.10.1314055
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A number of recent preclinical studies have demonstrated the potential role of cannabinoids and their receptors in bone metabolism. Pharmacological and genetic modulation of cannabinoid receptors indicate that cannabinoid ligands may provide attractive and novel agents for the treatment of bone diseases. This article reviews the role of cannabinoid receptors in regulating bone mass, bone loss and bone cell function in health and disease. The article also provides support to the notion that cannabinoid receptor ligands show a great promise in the treatment of bone diseases associated with accelerated osteoclastic bone resorption including osteoporosis, rheumatoid arthritis and bone metastasis.
引用
收藏
页码:533 / 540
页数:8
相关论文
共 100 条
[1]   Bone loss and bone size after menopause [J].
Ahlborg, HG ;
Johnell, O ;
Turner, CH ;
Rannevik, G ;
Karlsson, MK .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (04) :327-334
[2]  
Amling M, 2001, ADV EXP MED BIOL, V496, P85
[3]   Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase [J].
Armour, KE ;
Armour, KJ ;
Gallagher, ME ;
Gödecke, A ;
Helfrich, MH ;
Reid, DM ;
Ralston, SH .
ENDOCRINOLOGY, 2001, 142 (02) :760-766
[4]   Cannabinoid receptors and the regulation of bone mass [J].
Bab, I. ;
Zimmer, A. .
BRITISH JOURNAL OF PHARMACOLOGY, 2008, 153 (02) :182-188
[5]   Marijuana and cocaine impair alveolar macrophage function and cytokine production [J].
Baldwin, GC ;
Tashkin, DP ;
Buckley, DM ;
Park, AN ;
Dubinett, SM ;
Roth, MD .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 156 (05) :1606-1613
[6]   Evidence for novel cannabinoid receptors [J].
Begg, M ;
Pacher, P ;
Bátkai, S ;
Osei-Hyiaman, D ;
Offertáler, L ;
Mo, FM ;
Liu, H ;
Kunos, G .
PHARMACOLOGY & THERAPEUTICS, 2005, 106 (02) :133-145
[7]   Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes [J].
Bidinger, B ;
Torres, R ;
Rossetti, RG ;
Brown, L ;
Beltre, R ;
Burstein, S ;
Lian, JB ;
Stein, GS ;
Zurier, RB .
CLINICAL IMMUNOLOGY, 2003, 108 (02) :95-102
[8]   Endocannabinoids in endocrine and related tumours [J].
Bifulco, Maurizio ;
Malfitano, Anna Maria ;
Pisanti, Simona ;
Laezza, Chiara .
ENDOCRINE-RELATED CANCER, 2008, 15 (02) :391-408
[9]  
Bifulco M, 2007, ONCOL REP, V17, P813
[10]   Cannabinoids and cancer: pros and cons of an antitumour strategy [J].
Bifulco, Maurizio ;
Laezza, Chiara ;
Pisanti, Simona ;
Gazzerro, Patrizia .
BRITISH JOURNAL OF PHARMACOLOGY, 2006, 148 (02) :123-135