Viruses for Tumor Therapy

被引：124

作者：

Bell, John ^{[1
]}

McFadden, Grant ^{[2
]}

机构：

[1] Univ Ottawa, Ottawa Hosp Res Inst, Ctr Canc Therapeut, Ottawa, ON, Canada

[2] Univ Florida, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA

来源：

CELL HOST & MICROBE | 2014年 / 15卷 / 03期

关键词：

ONCOLYTIC VIRUSES; CLINICAL-TRIAL; CANCER; VIROTHERAPY; IMMUNOTHERAPY; VACCINES; CARRIERS; HUMANS;

D O I：

10.1016/j.chom.2014.01.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Oncolytic virotherapy exploits live viruses with selective tropism for cancerous cells and tissues to treat cancer. As discussed here, the field has progressed considerably as a result of both the successes and failures of previous and on-going clinical trials for various cancers. These studies indicate that oncolytic viruses are remarkably safe and more efficacious when virus replication stimulates sustained antitumor immune responses. In the future, virotherapy should be combined with immunomodulatory reagents that target immune tolerance to established cancers.

引用

页码：260 / 265

页数：6

共 29 条

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