A Self-Delivery Chimeric Peptide for Photodynamic Therapy Amplified Immunotherapy

被引：22

作者：

Cheng, Hong ^{[4
]}

Fan, Gui-Ling ^{[1
,2
,3
]}

Fan, Jing-Hao ^{[1
,2
,3
]}

Zheng, Rong-Rong ^{[1
,2
,3
]}

Zhao, Lin-Ping ^{[1
,2
,3
]}

Yuan, Ping ^{[1
,2
,3
]}

Zhao, Xiao-Ya ^{[1
,2
,3
]}

Yu, Xi-Yong ^{[1
,2
,3
]}

Li, Shi-Ying ^{[1
,2
,3
]}

机构：

[1] Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China

[2] Guangzhou Med Univ, Sch Pharmaceut Sci, State Key Lab Resp Dis, Guangzhou 511436, Guangdong, Peoples R China

[3] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China

[4] Southern Med Univ, Guangdong Prov Key Lab Construct & Detect Tissue, Biomat Res Ctr, Sch Biomed Engn, Guangzhou 510515, Guangdong, Peoples R China

来源：

MACROMOLECULAR BIOSCIENCE | 2019年 / 19卷 / 04期

基金：

中国国家自然科学基金;

关键词：

immunotherapy; melanoma; nano-vaccine; photodynamic therapy; self-delivery; IONIZING-RADIATION; NANOPARTICLES; COMBINATION; RESISTANCE; BLOCKADE; MELANOMA; PHOTOSENSITIZER; SUPPRESSION; METASTASIS; IMMUNITY;

D O I：

10.1002/mabi.201800410

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this paper, a self-delivery chimeric peptide PpIX-PEG(8)-KVPRNQDWL is designed for photodynamic therapy (PDT) amplified immunotherapy against malignant melanoma. After self-assembly into nanoparticles (designated as PPMA), this self-delivery system shows high drug loading rate, good dispersion, and stability as well as an excellent capability in producing reactive oxygen species (ROS). After cellular uptake, the ROS generated under light irradiation could induce the apoptosis and/or necrosis of tumor cells, which would subsequently stimulate the anti-tumor immune response. On the other hand, the melanoma specific antigen (KVPRNQDWL) peptide could also activate the specific cytotoxic T cells for anti-tumor immunity. Compared to immunotherapy alone, the combined photodynamic immunotherapy exhibits significantly enhanced inhibition of melanoma growth. Both in vitro and in vivo investigations confirm that PDT of PPMA has a positive effect on anti-tumor immune response. This self-delivery system demonstrates a great potential of this PDT amplified immunotherapy strategy for advanced or metastatic tumor treatment.

引用

页数：11

共 46 条

[1] Dendritic cells as therapeutic vaccines against cancer [J].