VEGFA rSNPs, transcriptional factor binding sites and human disease

被引：6
作者：
Buroker, Norman E. [1 ]
机构：
[1] Univ Washington, Dept Pediat, Seattle, WA 98195 USA
来源：
JOURNAL OF PHYSIOLOGICAL SCIENCES | 2014年 / 64卷 / 01期
关键词：
VEGFA; rSNP; TFBS; Human disease; ENDOTHELIAL GROWTH-FACTOR; GENOME-WIDE ASSOCIATION; OPEN-ACCESS DATABASE; FACTOR GENE; REGULATORY POLYMORPHISMS; FUNCTIONAL IMPLICATIONS; ANDROGEN RECEPTOR; IDENTIFICATION; COMPLICATIONS; MECHANISMS;
D O I：
10.1007/s12576-013-0293-4
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Three regulatory SNPs (rSNPs) in the promoter region of the vascular endothelial growth factor-A (VEGFA) gene have been significantly associated with several human diseases or conditions. The rSNP alleles alter the DNA landscape for potential transcriptional factors to attach, resulting in changes in transcriptional factor binding sites (TFBS). These TFBS changes are examined with respect to the human diseases which have been found to be significantly associated with the rSNPs.
引用
收藏
页码：73 / 76
页数：4
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