The human T-cell receptor repertoire in health and disease and potential for omics integration

被引：10

作者：

Watkins, Thomas S. ^{[1
,2
,3
]}

Miles, John J. ^{[1
,2
,3
]}

机构：

[1] James Cook Univ, Australian Inst Trop Hlth & Med AITHM, Cairns, Qld, Australia

[2] James Cook Univ, Ctr Mol Therapeut, Cairns, Qld, Australia

[3] James Cook Univ, Ctr Trop Bioinformat & Mol Biol, Cairns, Qld, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2021年 / 99卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

T cell; T-cell genetics; T-cell receptor; T-cell receptor sequencing; T-cell repertoire; MAJOR HISTOCOMPATIBILITY COMPLEX; TCR REPERTOIRES; ANTIGEN RECEPTOR; LYMPHOCYTES; DEEP; ACTIVATION; DIVERSITY; RESPONSES; SEQUENCE; REVEALS;

D O I：

10.1111/imcb.12377

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The adaptive immune system arose 600 million years ago in a cold-blooded fish. Over countless generations, our antecedents tuned the function of the T-cell receptor (TCR). The TCR system is arguably the most complex known to science. The TCR evolved hypervariability to fight the hypervariability of pathogens and cancers that look to consume our resources. This review describes the genetics and architecture of the human TCR and highlights surprising new discoveries over the past years that have disproved very old dogmas. The standardization of TCR sequencing data is discussed in preparation for big data bioinformatics and predictive analysis. We next catalogue new signatures and phenomenon discovered by TCR next generation sequencing (NGS) in health and disease and work that remain to be done in this space. Finally, we discuss how TCR NGS can add to immunodiagnostics and integrate with other omics platforms for both a deeper understanding of TCR biology and its use in the clinical setting.

引用

页码：135 / 145

页数：11

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