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- [7] Human T-Cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and-2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-Infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells JOURNAL OF VIROLOGY, 2007, 81 (18) : 9707 - 9717