Pathophysiology and treatment of obesity-related hypertension

被引：39

作者：

Chrysant, Steven G. ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, 5700 Mistletoe Court, Oklahoma City, OK 73142 USA

来源：

JOURNAL OF CLINICAL HYPERTENSION | 2019年 / 21卷 / 05期

关键词：

hypertension; mechanisms; obesity; treatment; NATRIURETIC PEPTIDES; KIDNEY-DISEASE; LEPTIN LEVEL; FAT; MECHANISMS; PRESSURE; SYSTEM; RISK; ALDOSTERONE; EXPRESSION;

D O I：

10.1111/jch.13518

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The prevalence of overweight and obesity has increased significantly in the United States and worldwide. Among the many complications of obesity, hypertension is the most common and major one accounting for about 70% in the obese subjects. However, the pathophysiologic factors of obesity-related hypertension and its therapeutic options are not well understood at present. To better understand the pathophysiology of obesity-related hypertension and its treatment options, a Medline search of the English language literature was contacted between 2010 and 2018 and 22 pertinent papers were selected. The information from these papers together with collateral literature will be discussed in this review.

引用

页码：555 / 559

页数：5

共 39 条

[1] Renin receptor expression in human adipose tissue [J].

Achard, Vincent ;

Boullu-Ciocca, Sandrine ;

Desbriere, Raoul ;

Nguyen, Genevieve ;

Grino, Michel .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2007, 292 (01) :R274-R282

[2] Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction [J].

Achari, Arunkumar E. ;

Jain, Sushil K. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (06)

[3] Leptin, Not Adiponectin, Predicts Hypertension in the Copenhagen City Heart Study [J].

Asferg, Camilla ;

Mogelvang, Rasmus ;

Flyvbjerg, Allan ;

Frystyk, Jan ;

Jensen, Jan S. ;

Marott, Jacob L. ;

Appleyard, Merete ;

Jensen, Gorm B. ;

Jeppesen, Jorgen .

AMERICAN JOURNAL OF HYPERTENSION, 2010, 23 (03) :327-333

[4] Higher serum leptin level in women than in men with type 1 diabetes [J].

Azar, ST ;

Salti, I ;

Zantout, MS ;

Shahine, CH ;

Zalloua, PA .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2002, 323 (04) :206-209

[5]

Benjamin EJ, 2017, CIRCULATION, V135, pE146, DOI [10.1161/CIR.0000000000000558, 10.1161/CIR.0000000000000485, 10.1161/CIR.0000000000000530]

[6] Obesity-induced increases in sympathetic nerve activity: Sex matters [J].

Brooks, Virginia L. ;

Shi, Zhigang ;

Holwerda, Seth W. ;

Fadel, Paul J. .

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2015, 187 :18-26

[7] Enhanced vascular activity of endogenous endothelin-1 in obese hypertensive patients [J].

Cardillo, C ;

Campia, U ;

Iantorno, M ;

Panza, JA .

HYPERTENSION, 2004, 43 (01) :36-40

[8] The Relationship of Body Mass and Fat Distribution With Incident Hypertension Observations From the Dallas Heart Study [J].

Chandra, Alvin ;

Neeland, Ian J. ;

Berry, Jarett D. ;

Ayers, Colby R. ;

Rohatgi, Anand ;

Das, Sandeep R. ;

Khera, Amit ;

McGuire, Darren K. ;

de Lemos, James A. ;

Turer, Aslan T. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 64 (10) :997-1002

[9] Promising cardiovascular and blood pressure effects of the SGLT2 inhibitors: a new class of antidiabetic drugs [J].

Chrysant, S. G. .

DRUGS OF TODAY, 2017, 53 (03) :191-202

[10] Pharmacokinetic, pharmacodynamic, and antihypertensive effects of the neprilysin inhibitor LCZ-696: sacubitril/valsartan [J].

Chrysant, Steven G. .

JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, 2017, 11 (07) :461-468

← 1 2 3 4 →