Synthesis and anti-inflammatory activity of some [4,6-(4-substituted aryl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-acetic acid derivatives

被引：164

作者：

Bahekar, SS ^{[1
]}

Shinde, DB ^{[1
]}

机构：

[1] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem Technol, Aurangabad 431004, Maharashtra, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 07期

关键词：

pyrimidine; anti-inflammatory activity; aryl alkanoic acids; NSAIDs;

D O I：

10.1016/j.bmcl.2004.01.039

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of [4,6-(substituted aryl)-2-thioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetic acid (4a-r) has been synthesized by the base catalyzed condensation of beta-aroylpropionic acid, thiourea with aldehyde in ethanol. Structures of the new compound were established on the basis of H-1 NMR and IR spectral data. Anti-inflammatory activity in vivo were evaluated and compared with standard drug diclofenac sodium. Some compounds have shown moderate activity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1733 / 1736

页数：4

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