QuEChERS and ultra-high performance liquid chromatography-tandem mass spectrometry method for the determination of parabens and ultraviolet filters in human milk samples

被引：31

作者：

Vela-Soria, F. ^{[1
]}

Iribarne-Duran, L. M. ^{[1
]}

Mustieles, V. ^{[1
]}

Jimenez-Diaz, I. ^{[1
,2
]}

Fernandez, M. F. ^{[1
,2
,3
]}

Olea, N. ^{[1
,2
,3
]}

机构：

[1] Hosp Univ Granada, Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain

[2] CIBERESP, Barcelona, Spain

[3] Univ Granada, Dept Radiol & Med Fis, Granada, Spain

来源：

JOURNAL OF CHROMATOGRAPHY A | 2018年 / 1546卷

基金：

欧盟地平线“2020”;

关键词：

Endocrine disrupting chemicals; Parabens; UV-filters; Human milk; QuECHERS; UHPLC-MS/MS; ENDOCRINE-DISRUPTING CHEMICALS; HUMAN BREAST-MILK; UV-FILTERS; BISPHENOL-A; UHPLC-MS/MS; HUMAN URINE; CHLORINATED DERIVATIVES; DEVELOPMENTAL TOXICITY; EXTRACTION PROCEDURE; ASSISTED EXTRACTION;

D O I：

10.1016/j.chroma.2018.02.060

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Concerns are growing about human exposure to endocrine disrupting chemicals (EDCs), especially during developmental stages. Parabens (PBs) and ultraviolet filters (UVFs) are prevalent EDCs widely used as additives in cosmetics and personal care products (PCPs). The objective of this study was to develop a method to determine four PBs and ten UVFs in human milk using QuEChERS treatment and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Multivariate strategies were applied to optimize experimental parameters. Limits of quantification ranged from 0.1 to 0.2 ng mL(-1) and inter-day variability (evaluated as relative standard deviation) from 6% to 13%. The method was validated using matrix-matched standard calibration followed by a recovery assay with spiked samples. Recovery percentages ranged from 87% to 112%. The method was satisfactorily applied to assess target compounds in human milk samples from 15 donors. This analytical procedure can provide information on newborn exposure to these EDCs. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：1 / 9

页数：9

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