What is the role of TDP-43 in C9orf72-related amyotrophic lateral sclerosis and frontemporal dementia?

被引：8
|
作者：
Scaber, Jakub [1 ]
Talbot, Kevin [1 ]
机构：
[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford OX3 9DU, England
来源：
BRAIN | 2016年 / 139卷
基金：
英国医学研究理事会;
关键词：
FRONTOTEMPORAL LOBAR DEGENERATION; DIPEPTIDE REPEAT PROTEINS; MOTOR-NEURON DISEASE; C9ORF72; EXPANSIONS; PATHOLOGY;
D O I：
10.1093/brain/aww264
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
引用
收藏
页码：3057 / 3059
页数：4
相关论文
共 50 条
  • [21] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
    Oiwa, Kotaro
    Watanabe, Seiji
    Onodera, Kazunari
    Iguchi, Yohei
    Kinoshita, Yukako
    Komine, Okiru
    Sobue, Akira
    Okada, Yohei
    Katsuno, Masahisa
    Yamanaka, Koji
    SCIENCE ADVANCES, 2023, 9 (31)
  • [22] Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis
    Kasai, Takashi
    Tokuda, Takahiko
    Ishigami, Noriko
    Sasayama, Hiroshi
    Foulds, Penelope
    Mitchell, Douglas J.
    Mann, David M. A.
    Allsop, David
    Nakagawa, Masanori
    ACTA NEUROPATHOLOGICA, 2009, 117 (01) : 55 - 62
  • [23] Therapeutic strategies for C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia
    Hautbergue, Guillaume M.
    Cleary, John D.
    Guo, Shu
    Ranum, Laura P. W.
    CURRENT OPINION IN NEUROLOGY, 2021, 34 (05) : 748 - 755
  • [24] TDP-43 Redistribution is an Early Event in Sporadic Amyotrophic Lateral Sclerosis
    Giordana, Maria Teresa
    Piccinini, Marco
    Grifoni, Silvia
    De Marco, Giovanni
    Vercellino, Marco
    Magistrello, Michela
    Pellerino, Alessia
    Buccinna, Barbara
    Lupino, Elisa
    Rinaudo, Maria Teresa
    BRAIN PATHOLOGY, 2010, 20 (02) : 351 - 360
  • [25] Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
    Prasad, Archana
    Bharathi, Vidhya
    Sivalingam, Vishwanath
    Girdhar, Amandeep
    Patel, Basant K.
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2019, 12
  • [26] Increased expression of TDP-43 in the skin of amyotrophic lateral sclerosis
    Suzuki, M.
    Mikami, H.
    Watanabe, T.
    Yamano, T.
    Yamazaki, T.
    Nomura, M.
    Yasui, K.
    Ishikawa, H.
    Ono, S.
    ACTA NEUROLOGICA SCANDINAVICA, 2010, 122 (05): : 367 - 372
  • [27] Pathogenic Mechanisms and Therapy Development for C9orf72 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
    Jiang, Jie
    Ravits, John
    NEUROTHERAPEUTICS, 2019, 16 (04) : 1115 - 1132
  • [28] TDP-43 plasma levels are higher in amyotrophic lateral sclerosis
    Verstraete, Esther
    Kuiperij, H. Bea
    van Blitterswijk, Marka M.
    Veldink, Jan H.
    Schelhaas, H. Jurgen
    van den Berg, Leonard H.
    Verbeek, Marcel M.
    AMYOTROPHIC LATERAL SCLEROSIS, 2012, 13 (05): : 446 - 451
  • [29] Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis
    Cykowski, Matthew D.
    Powell, Suzanne Z.
    Peterson, Leif E.
    Appel, Joan W.
    Rivera, Andreana L.
    Takei, Hidehiro
    Chang, Ellen
    Appel, Stanley H.
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2017, 76 (05) : 402 - 413
  • [30] TDP-43 and Phosphorylated TDP-43 Levels in Paired Plasma and CSF Samples in Amyotrophic Lateral Sclerosis
    Ren, Yuting
    Li, Siyuan
    Chen, Siyu
    Sun, Xiaosun
    Yang, Fei
    Wang, Hongfen
    Li, Mao
    Cui, Fang
    Huang, Xusheng
    FRONTIERS IN NEUROLOGY, 2021, 12
12345