Domino Heck-Aza-Michael Reactions: A One-Pot, Sequential Three-Component Approach to 1.1-Dioxido-1,2-benzisothiazoline-3-acetic Acid

被引：54

作者：

Rolfe, Alan ^{[1
,2
]}

Young, Kyle ^{[1
,2
]}

Hanson, Paul R. ^{[1
,2
]}

机构：

[1] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA

[2] Univ Kansas, Ctr Chem Methodol & Lib Dev, Lawrence, KS 66047 USA

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 2008卷 / 31期

基金：

美国国家卫生研究院;

关键词：

Domino reactions; Sultams; Heck reaction; Aza-Michael reaction; Multicomponent reactions;

D O I：

10.1002/ejoc.200800651

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of a new method for the synthesis of 1,1dioxido-1,2-benzisothiazoline-3-acetic acid by a domino process is reported whereby a classical Heck reaction is coupled to an intramolecular aza-Michael reaction. Ultimately, this method has been expanded to a one-pot, sequential three-component protocol to generate diverse benzofused gamma-sultams from a range of commercially available alpha-bromobenzenesulfonyl chlorides, amines and Michael acceptors. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

引用

页码：5254 / 5262

页数：9

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