Risk Factors for Frequent Severe Exacerbations in Late-Onset Eosinophilic Asthma

被引:20
作者
de Groot, Jantina C. [1 ]
Amelink, Marijke [2 ]
de Nijs, Selma B. [2 ]
Plaat, Robin [1 ]
Reitsma, Bennie H. [1 ]
Storm, Huib [1 ]
Bel, Elisabeth H. D. [2 ]
ten Brinke, Anneke [1 ]
机构
[1] Med Ctr Leeuwarden, Leeuwarden, Netherlands
[2] Amsterdam Med Ctr, Amsterdam, Netherlands
关键词
CONTROLLED TRIAL; PHENOTYPES;
D O I
10.1164/rccm.201505-1003LE
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
引用
收藏
页码:899 / 902
页数:4
相关论文
共 10 条
[1]   Severe adult-onset asthma: A distinct phenotype [J].
Amelink, Marijke ;
de Groot, Jantina C. ;
de Nijs, Selma B. ;
Lutter, Rene ;
Zwinderman, Aeilko H. ;
Sterk, Peter J. ;
ten Brinke, Anneke ;
Bel, Elisabeth H. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 132 (02) :336-341
[2]   Asthma phenotypes and the use of biologic medications in asthma and allergic disease: The next steps toward personalized care [J].
Fajt, Merritt L. ;
Wenzel, Sally E. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 135 (02) :299-311
[3]   Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial [J].
Green, RH ;
Brightling, CE ;
McKenna, S ;
Hargadon, B ;
Parker, D ;
Bradding, P ;
Wardlaw, AJ ;
Pavord, ID .
LANCET, 2002, 360 (9347) :1715-1721
[4]   Cluster analysis and clinical asthma phenotypes [J].
Haldar, Pranab ;
Pavord, Ian D. ;
Shaw, Dominic E. ;
Berry, Michael A. ;
Thomas, Michael ;
Brightling, Christopher E. ;
Wardlaw, Andrew I. ;
Green, Ruth H. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 178 (03) :218-224
[5]   Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial [J].
Pavord, Ian D. ;
Korn, Stephanie ;
Howarth, Peter ;
Bleecker, Eugene R. ;
Buhl, Roland ;
Keene, Oliver N. ;
Ortega, Hector ;
Chanez, Pascal .
LANCET, 2012, 380 (9842) :651-659
[6]   Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation [J].
Sorkness, Ronald L. ;
Bleecker, Eugene R. ;
Busse, William W. ;
Calhoun, William J. ;
Castro, Mario ;
Chung, Kian Fan ;
Curran-Everett, Douglas ;
Erzurum, Serpil C. ;
Gaston, Benjamin M. ;
Israel, Elliot ;
Jarjour, Nizar N. ;
Moore, Wendy C. ;
Peters, Stephen P. ;
Teague, W. Gerald ;
Wenzel, Sally E. .
JOURNAL OF APPLIED PHYSIOLOGY, 2008, 104 (02) :394-403
[7]   Refractory eosinophilic airway inflammation in severe asthma - Effect of parenteral corticosteroids [J].
ten Brinke, A ;
Zwinderman, AH ;
Sterk, PJ ;
Rabe, KF ;
Bel, EH .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 170 (06) :601-605
[8]   Sputum induction in severe asthma by a standardized protocol - Predictors of excessive bronchoconstriction [J].
ten Brinke, A ;
de Lange, C ;
Zwinderman, AH ;
Rabe, KF ;
Sterk, PJ ;
Bel, EH .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 164 (05) :749-753
[9]   Dupilumab in Persistent Asthma with Elevated Eosinophil Levels [J].
Wenzel, Sally ;
Ford, Linda ;
Pearlman, David ;
Spector, Sheldon ;
Sher, Lawrence ;
Skobieranda, Franck ;
Wang, Lin ;
Kirkesseli, Stephane ;
Rocklin, Ross ;
Bock, Brian ;
Hamilton, Jennifer ;
Ming, Jeffrey E. ;
Radin, Allen ;
Stahl, Neil ;
Yancopoulos, George D. ;
Graham, Neil ;
Pirozzi, Gianluca .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (26) :2455-2466
[10]   Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data [J].
Wu, Wei ;
Bleecker, Eugene ;
Moore, Wendy ;
Busse, William W. ;
Castro, Mario ;
Chung, Kian Fan ;
Calhoun, William J. ;
Erzurum, Serpil ;
Gaston, Benjamin ;
Israel, Elliot ;
Curran-Everett, Douglas ;
Wenzel, Sally E. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 133 (05) :1280-1288