Interferon-gamma Release Assays for the Diagnosis of Latent Tuberculosis Infection: an Updated Review

被引:2
作者
Moon, Hee-Won [1 ]
Hur, Mina [1 ]
机构
[1] Konkuk Univ, Sch Med, Dept Lab Med, Seoul 143729, South Korea
关键词
HEALTH-CARE WORKERS; QUANTIFERON-TB GOLD; MYCOBACTERIUM-TUBERCULOSIS; ACTIVE TUBERCULOSIS; SKIN-TEST; PREDICTIVE-VALUE; COST-EFFECTIVENESS; GUIDELINES; CHILDREN; DISEASE;
D O I
暂无
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Interferon-gamma (IFN-gamma) release assays (IGRAs) are in vitro immune tests that have recently been introduced as an alternative to the tuberculin skin test (TST). An increasing body of evidence supports the use of IGRAs for the diagnosis of latent tuberculosis infection (LTBI) in various clinical situations. Currently, two commercial IGRAs are available: the QuantiFERON-TB Gold In-Tube test (QFT-GIT, Cellestis Ltd, Carnegie, Australia) and the T-SPOT TB assay (T-SPOT, Oxford Immunotec Ltd., Abingdon, UK). Though the clinical performances of these two IGRAs varied widely according to the characteristics of each study, they were reported to be better than those of TST in most cases. In this concise review, the performance characteristics, the use in special clinical situations, and the guidelines of IGRAs are presented.
引用
收藏
页码:221 / 229
页数:9
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