Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats

被引：42

作者：

Chen, Z ^{[1
]}

Zhao, Q ^{[1
]}

Sugimoto, Y ^{[1
]}

Fujii, Y ^{[1
]}

Kamei, C ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Dept Pharmacol, Okayama 7008530, Japan

来源：

BRAIN RESEARCH | 1999年 / 839卷 / 01期

关键词：

MK-801; histamine; H-1-receptor; H-3-receptor; radial maze performance;

D O I：

10.1016/S0006-8993(99)01739-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of histamine on the spatial memory deficits induced by MK-801 were investigated using the eight-arm radial maze paradigm in rats. Intracerebroventricular (i.c.v.) injection of histamine or thioperamide, and intraperitoneal (i.p.) injection of histidine improved the spatial memory deficits induced by MK-801. Similar results were obtained with 2-thiazolylethylamine. In contrast, 4-methylhistamine showed no significant effect. Based on these observations, it seems likely that the protective effect of histamine on MK-801-induced spatial memory deficit is mediated by H-1-receptors. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：186 / 189

页数：4

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