Regulatory mechanisms of branching morphogenesis in mouse submandibular gland rudiments

被引:6
作者
Kashimata, Masanori [1 ]
Hayashi, Toru [2 ]
机构
[1] Asahi Univ, Sch Dent, Dept Pharmacol, 1851-1 Hozumi, Mizuho, Gifu 5010296, Japan
[2] Kitasato Univ, Lab Anat & Histol, Basic Med Sci & Clin Med, Sch Allied Hlth Sci,Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520373, Japan
关键词
Salivary gland; Branching morphogenesis; Epidermal growth factor; Integrin; ERK1/2; cascade; microRNA; EPIDERMAL-GROWTH-FACTOR; RECEPTOR TYROSINE KINASES; SALIVARY-GLAND; EPITHELIAL MORPHOGENESIS; SIGNALING PATHWAYS; TGF-BETA; IN-VITRO; EXPRESSION; EGF; ACTIVATION;
D O I
10.1016/j.jdsr.2017.06.002
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Branching morphogenesis is an important developmental process for many organs, including the salivary glands. Whereas epithelial-mesenchymal interactions, which are cell-to-cell communications, are known to drive branching morphogenesis, the molecular mechanisms responsible for those inductive interactions are still largely unknown. Cell growth factors and integrins are known to be regulators of branching morphogenesis of salivary glands. In addition, functional microRNAs (miRNAs) have recently been reported to be present in the developing submandibular gland. In this review, the authors describe the roles of various cell growth factors, integrins and miRNAs in branching morphogenesis of developmental mouse submandibular glands. (C) 2018 The Authors. Published by Elsevier Ltd.
引用
收藏
页码:2 / 7
页数:6
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