Predictive factors used to justify hysterectomy after loop conization: Increasing age and severity of disease

Objective: To determine the interpretability and significance of the traditional factors used to predict residual dysplasia in hysterectomy specimens after loop conization. Materials and Methods: Loop electrosugical cervical conization was performed on 372 patients. Ninety three women had a hysterectomy within 6 months of the loop conization. Residual disease was defined as cervical intraepithelial neoplasia or-cancer in the hysterectomy specimen. Results: Of the 93 patients having a subsequent hysterectomy, 36 (38.7%) has residual disease in their hysterectomy specimen. The mean age of the patients with residual disease in the post loop conization hysterectomy specimen was 42.22. The mean ase of those free of residual disease was 29.42. By multivariate analysis, dysplasia involving the ectocervical margin (p=0.34) and the endocervical margin (p=0.35) was not predictive of disease in the hysterectomy specimens. Endocervical curettage (p=0.005), glandular involvement (p=0.01), loop conization pathology findings (p<0.05) and cytological examination (p<0.001) were predictive of residual dysplasia. Conclusions: Cytological reports, increasing age, severity of disease, gland involvement and endocervical curettage were the only factors that accurately predicted residual dysplasia. The presence or absence of dysplasia in the loop conization, ectocervical margin and endocervical margin was not predictive of residual dysplasia in post loop conization hysterectomy specimens.